abstract：:Interferon-β (IFN-β) is known to expand regulatory CD56(bright) natural killer (NK) cells in multiple sclerosis (MS). In this cross-sectional study we show that MS patients treated with IFN-β alone or in combination with low-dose prednisolone displayed increased proportion of all NK cell subsets in the active phase of...

journal_title：Journal of neuroimmunology

authors： Sanvito L,Tomita A,Chihara N,Okamoto T,Lin Y,Ogawa M,Gran B,Aranami T,Yamamura T

更新日期：2011-07-01 00:00:00

abstract：:Single nucleotide polymorphisms in human pro- and anti-inflammatory genes, including IL1RN VNTR (rs315952), IL1A 4845G>T (rs17561), L1B-511C>T (rs16944), IL6-174G>C (rs1800795), IL10-1082 A>G (rs 1800896) and TNFα-308G>A (rs1800629) and their impact on multiple sclerosis risk and disease progression in a Polish popula...

journal_title：Journal of neuroimmunology

authors： Mirowska-Guzel D,Gromadzka G,Mach A,Czlonkowski A,Czlonkowska A

更新日期：2011-07-01 00:00:00

abstract：:Interleukin-6 (IL-6) can activate gastrointestinal submucosal neurons, with associated implications for motility and secretory function. Patients with irritable bowel syndrome (IBS) have elevated levels of circulating IL-6. Colons from the Wistar Kyoto (WKY) rat model of IBS secrete more IL-6 (12.84 pg/ml) than contro...

journal_title：Journal of neuroimmunology

authors： O'Malley D,Dinan TG,Cryan JF

更新日期：2011-06-01 00:00:00

abstract：:Multiple sclerosis (MS) patients make antibodies to heterogeneous nuclear ribonuclear protein A1 (hnRNP-A1), a nucleocytoplasmic protein. We hypothesized this autoimmune reaction might contribute to neurodegeneration. Antibodies from MS patients reacted with hnRNP-A1-'M9', its nuclear translocation sequence. Transfect...

journal_title：Journal of neuroimmunology

authors： Lee S,Xu L,Shin Y,Gardner L,Hartzes A,Dohan FC,Raine C,Homayouni R,Levin MC

更新日期：2011-06-01 00:00:00

abstract：:Patients with multiple sclerosis (MS) show a high prevalence of myelin-reactive CD8+ and CD4+ T-cell responses, which are the putative effectors/modulators of CNS neuropathology. Utilizing a novel combination of short-term culture, CFSE-based sorting and anchored PCR, we evaluated clonal compositions of neuroantigen-t...

journal_title：Journal of neuroimmunology

authors： Biegler BW,Yan SX,Ortega SB,Tennakoon DK,Racke MK,Karandikar NJ

更新日期：2011-05-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-α) is a cytokine with pleiotropic actions that can be present both as a transmembrane protein and soluble cytokine (sTNF). Both ligands interact with two different receptors, TNFR1 and TNFR2, which mediate their biological effects. TNF-α is involved in the pathogenesis of multiple scle...

journal_title：Journal of neuroimmunology

authors： Caminero A,Comabella M,Montalban X

更新日期：2011-05-01 00:00:00

abstract：:Suppressors of cytokine signaling (SOCS) negatively regulate the immune response, primarily by interfering with the JAK/STAT pathway. We have developed a small peptide corresponding to the kinase inhibitory region (KIR) sequence of SOCS-1, SOCS1-KIR, which inhibits kinase activity by binding to the activation loop of ...

journal_title：Journal of neuroimmunology

authors： Jager LD,Dabelic R,Waiboci LW,Lau K,Haider MS,Ahmed CM,Larkin J 3rd,David S,Johnson HM

更新日期：2011-03-01 00:00:00

abstract：:2D-immunomics may be useful in the identification of autoantigens in neurological autoimmune diseases, but its application may be limited by denaturation of target proteins. Here we compared the capacity of a single or multiple antigens to elicit autoantibodies targeting multiple neural autoantigens by ELISA and 2D-im...

journal_title：Journal of neuroimmunology

authors： Farinazzo A,Gini B,Milli A,Ruffini F,Marconi S,Turano E,Anghileri E,Barbieri F,Cecconi D,Furlan R,Bonetti B

更新日期：2011-03-01 00:00:00

abstract：:Progressive multifocal leukoencephalopathy (PML) is a disease of the central nervous system (CNS) with destructive infection of oligodendrocytes by JC virus. PML belongs to the opportunistic infections. It is observed in patients with HIV infection, lymphoid malignancies, after organ- and stem cell transplantations an...

journal_title：Journal of neuroimmunology

authors： Weissert R

更新日期：2011-02-01 00:00:00

abstract：:Neuromyelitis optica (NMO) is a rare demyelinating disease, affecting selectively the optic nerve and the spinal cord. It was previously considered to be a severe variant of multiple sclerosis (MS) due to the similar pathological features and its resemblance to optico-spinal, or Japanese, MS, typical of Asian populati...

journal_title：Journal of neuroimmunology

authors： Fazio R,Radaelli M,Furlan R

更新日期：2011-02-01 00:00:00

abstract：:Despite a number of new therapies that are effective in reducing the inflammatory component of multiple sclerosis, the underlying cause of the disease remains uncertain. One of the most powerful tools available to an investigator to help in unraveling the underlying disease mechanisms in MS is the incorporation of car...

journal_title：Journal of neuroimmunology

authors： McFarland H

更新日期：2011-02-01 00:00:00

abstract：:The multifaceted pathogenesis of multiple sclerosis (MS) involves complex interactions between the immune and the central nervous systems which provide a multitude of targets for therapeutic interventions. Current therapies for MS are only partially effective. One potential strategy to increase treatment efficacy is t...

journal_title：Journal of neuroimmunology

authors： Milo R,Panitch H

更新日期：2011-02-01 00:00:00

abstract：:Stroke may be accompanied by immunological consequences including local autoimmunity and peripheral immune suppression. Since the blood brain barrier is disturbed cells of the immune system gain direct access to the brain parenchyma. Here local autoimmunity contributes to lesion formation and, in experimental stroke, ...

journal_title：Journal of neuroimmunology

authors： Vogelgesang A,Dressel A

更新日期：2011-02-01 00:00:00

abstract：:We measured circulating serum and cerebrospinal fluid (CSF) concentrations of B lymphocyte activating factor of the tumour necrosis factor superfamily (BAFF), and determined total and Epstein-Barr virus (EBV)-specific oligoclonal IgG bands (OCBs) in 43 patients with multiple sclerosis (MS), 23 patients with other infl...

journal_title：Journal of neuroimmunology

authors： Franciotta D,Di Stefano AL,Jarius S,Zardini E,Tavazzi E,Ballerini C,Marchioni E,Bergamaschi R,Ceroni M

更新日期：2011-01-01 00:00:00

abstract：:CD4+CD25+ regulatory T cells (Treg) transform the HIV-1 infected macrophage from a neurotoxic to a neuroprotective phenotype. This was demonstrated previously in a murine model of HIV-1 encephalitis induced by intracranial injection of HIV-1/vesicular stomatitis virus-infected bone marrow macrophages. In this report, ...

journal_title：Journal of neuroimmunology

authors： Gong N,Liu J,Reynolds AD,Gorantla S,Mosley RL,Gendelman HE

更新日期：2011-01-01 00:00:00

abstract：:X-linked adrenoleukodystrophy (X-ALD) is a severe neurological disease characterized by progressive demyelination within the CNS, adrenal insufficiency, and is associated with an accumulation of saturated very long chain fatty acids in plasma and tissues of patients. iNKT cells, a distinct lineage of T cells recognizi...

journal_title：Journal of neuroimmunology

authors： Gautron AS,Giquel B,Beaudoin L,Autrusseau E,Speak A,Platt F,Kemp S,Pujol A,Aubourg P,Lehuen A

更新日期：2010-12-15 00:00:00

abstract：:We investigated T cell immunity to Epstein-Barr virus (EBV) in multiple sclerosis (MS) and assessed cross-reactivity of the anti-EBV cellular response with brain antigens. We measured the proliferation, cytotoxicity, and number of interferon-γ secreting cells following stimulation with autologous EBV-infected lymphobl...

journal_title：Journal of neuroimmunology

authors： Lindsey JW,Hatfield LM

更新日期：2010-12-15 00:00:00

abstract：:Multiple sclerosis (MS) is a demyelinating disease characterized by the breakdown of the blood-brain barrier (BBB), and accumulation of inflammatory infiltrates in the central nervous system. Tight junctions are specialized cell-cell adhesion structures and critical components of the BBB that have previously been show...

journal_title：Journal of neuroimmunology

authors： Bennett J,Basivireddy J,Kollar A,Biron KE,Reickmann P,Jefferies WA,McQuaid S

更新日期：2010-12-15 00:00:00

abstract：:Wild-type mice control murine cytomegalovirus (MCMV) brain infection, but identical infection is lethal to animals deficient in interleukin (IL)-10. Here, we report that MCMV-infected IL-10 knockout (KO) mice displayed a marked increase in neutrophil infiltration into the infected, IL-10-deficient brain when compared ...

journal_title：Journal of neuroimmunology

authors： Mutnal MB,Cheeran MC,Hu S,Little MR,Lokensgard JR

更新日期：2010-10-08 00:00:00

abstract：:Differences in the regulation of surface molecule expression and functional activity of microglia, the resident immune effector elements of the central nervous system (CNS), might give important insights into understanding the predilection sites of some diseases within the CNS. Therefore, canine microglial cells in re...

journal_title：Journal of neuroimmunology

authors： Ensinger EM,Boekhoff TM,Carlson R,Beineke A,Rohn K,Tipold A,Stein VM

更新日期：2010-10-08 00:00:00

abstract：:Using a transgenic mouse model of ischemic stroke we checked for a possible interaction of antiphospholipid antibodies (aPL) which often cause thromboses as well as central nervous system (CNS) involvement under non-thrombotic conditions and the TWEAK/Fn14 pathway known to be adversely involved in inflammatory and isc...

journal_title：Journal of neuroimmunology

authors： Frauenknecht K,Bargiotas P,Bauer H,von Landenberg P,Schwaninger M,Sommer C

更新日期：2010-10-08 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory immune response directed against myelin antigens of the central nervous system. In its murine model, EAE, Th17 cells play an important role in disease pathogenesis. These cells can induce blood-brain barrier disruption and CNS immune cells ...

journal_title：Journal of neuroimmunology

authors： Peron JP,Yang K,Chen ML,Brandao WN,Basso AS,Commodaro AG,Weiner HL,Rizzo LV

更新日期：2010-10-08 00:00:00

abstract：:Glatiramer acetate (GA) is an immunomodulator approved for therapy of relapsing-remitting multiple sclerosis (RRMS), but recent findings indicate that it may also have additional, neurotrophic effects. Here, we found that supernatants from human GA-reactive T lymphocytes potentiated oligodendrocyte numbers in rodent a...

journal_title：Journal of neuroimmunology

authors： Zhang Y,Jalili F,Ouamara N,Zameer A,Cosentino G,Mayne M,Hayardeny L,Antel JP,Bar-Or A,John GR

更新日期：2010-10-08 00:00:00

abstract：:Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we gen...

journal_title：Journal of neuroimmunology

authors： Lorentzen AR,Melum E,Ellinghaus E,Smestad C,Mero IL,Aarseth JH,Myhr KM,Celius EG,Lie BA,Karlsen TH,Franke A,Harbo HF

更新日期：2010-09-14 00:00:00

abstract：:The present study tested whether aging sensitizes hippocampal microglia to a pro-inflammatory challenge ex vivo. Hippocampal microglia from 3 and 24 mo old male F344 x BN F1 rats were exposed to LPS (0, 0.1, 1, 10 and 100 ng/ml) ex vivo. 2 h post-LPS challenge, gene expression of microglial activation markers and cyto...

journal_title：Journal of neuroimmunology

authors： Frank MG,Barrientos RM,Watkins LR,Maier SF

更新日期：2010-09-14 00:00:00

abstract：:Theiler's murine encephalomyelitis virus (TMEV) establishes a persistent infection in the central nervous system (CNS). To examine the role of type I interferon (IFN-I)-mediated signals in TMEV infection, mice lacking a subunit of the type I IFN receptor (IFN-IR KO mice) were utilized. In contrast to wild type mice, I...

journal_title：Journal of neuroimmunology

authors： Jin YH,Hou W,Kim SJ,Fuller AC,Kang B,Goings G,Miller SD,Kim BS

更新日期：2010-09-14 00:00:00

abstract：:Myelin-reactive T helper-17 cells are implicated in the pathogenesis of multiple sclerosis (MS). Here, we analyzed the reactivity of peripheral naive and memory conventional CD4(+)CD127(high) T cells (Tconv) of MS patients and healthy controls (HC) towards myelin basic protein (MBP), myelin oligodendrocyte glycoprotei...

journal_title：Journal of neuroimmunology

authors： Venken K,Hellings N,Hensen K,Rummens JL,Stinissen P

更新日期：2010-09-14 00:00:00

abstract：OBJECTIVE:The risk of multiple sclerosis (MS) is influenced by HLA-DRB1, while protective effects have been proposed for HLA-A*02 and HLA-C*05. Our aim was to further understand the role of HLA class I in MS through a comprehensive investigation. METHODS:1529 MS patients and 1814 controls from Sweden and Norway were g...

journal_title：Journal of neuroimmunology

authors： Link J,Lorentzen AR,Kockum I,Duvefelt K,Lie BA,Celius EG,Harbo HF,Hillert J,Brynedal B

更新日期：2010-09-14 00:00:00

abstract：:Intranasal application of vesicular stomatitis virus (VSV) induces acute encephalitis characterized by a pronounced myeloid and T cell infiltrate. The role of distinct phagocytic populations on VSV encephalitis was therefore examined in this study. Ablation of peripheral macrophages did not impair VSV encephalitis or ...

journal_title：Journal of neuroimmunology

authors： Steel CD,Kim WK,Sanford LD,Wellman LL,Burnett S,Van Rooijen N,Ciavarra RP

更新日期：2010-09-14 00:00:00

abstract：:PI-2301 is an immunomodulator that could be an alternative therapy for MS. A placebo-controlled, multiple-ascending dose, double-blind study was performed in patients with secondary-progressive MS. Treatment was given subcutaneously once weekly for 8 weeks, followed by a 4-week open-label treatment period with active ...

journal_title：Journal of neuroimmunology

authors： Kovalchin J,Krieger J,Genova M,Collins K,Augustyniak M,Masci A,Hittinger T,Kuca B,Edan G,Braudeau C,Rimbert M,Patel U,Mascioli E,Zanelli E

更新日期：2010-08-25 00:00:00

abstract：:Recombinant T cell ligands (RTLs) ameliorate experimental autoimmune encephalomyelitis (EAE) in an antigen-specific manner. We evaluated effects of RTL401 (I-A(s) alpha1beta1+PLP-139-151) on splenocytes from SJL/J mice with EAE to study RTL-T cell tolerance-inducing mechanisms. RTLs bound to B, macrophages and DCs, th...

journal_title：Journal of neuroimmunology

authors： Sinha S,Miller L,Subramanian S,McCarty OJ,Proctor T,Meza-Romero R,Huan J,Burrows GG,Vandenbark AA,Offner H

更新日期：2010-08-25 00:00:00

abstract：:Chemokines are critical mediators of immune cell entry into the central nervous system (CNS), as occurs in neuroinflammatory disease such as multiple sclerosis. Chemokines are also implicated in the immune response to viral infections. Many viruses encode proteins that mimic or block chemokine actions, in order to eva...

journal_title：Journal of neuroimmunology

authors： Millward JM,Holst PJ,Høgh-Petersen M,Thomsen AR,Christensen JP,Owens T

更新日期：2010-07-27 00:00:00

abstract：:Tumorigenesis requires interactions between tumor progenitors and their microenvironment. We found that low cAMP levels were sufficient for tumorigenesis in a mouse model of Neurofibromatosis-1 (NF1)-associated optic pathway glioma (OPG). We hypothesized that the distinct pattern of glioma in NF1 reflected spatiotempo...

journal_title：Journal of neuroimmunology

authors： Sun T,Gianino SM,Jackson E,Piwnica-Worms D,Gutmann DH,Rubin JB

更新日期：2010-07-27 00:00:00

abstract：:Antigen presentation, a key mechanism in immune responses, involves two main signals: the first is provided by the engagement of a major histocompatibility complex (MHC), class I or class II, with their TCR receptor in lymphocytes, whereas the second demands the participation of different co-stimulatory molecules, suc...

journal_title：Journal of neuroimmunology

authors： Almolda B,González B,Castellano B

更新日期：2010-06-01 00:00:00

abstract：:Immunological changes initiated by major operative injury may result in inflammatory responses in both peripheral and central nervous system, which may lead to organ dysfunction. Recent studies indicate that beta-adrenergic receptors (beta-ARs) may mediate production of pro-inflammatory cytokines in the brain. In the ...

journal_title：Journal of neuroimmunology

authors： Wang J,Li J,Sheng X,Zhao H,Cao XD,Wang YQ,Wu GC

更新日期：2010-06-01 00:00:00

abstract：:A recent meta-analysis of genome-wide association screens coupled to a replication exercise in a combined US/UK collection led to the identification of 4 single nucleotide polymorphisms (SNPs) in three gene loci, i.e. TNFRSF1A, CD6 and IRF8, as novel risk factors for multiple sclerosis with genome-wide level of signif...

journal_title：Journal of neuroimmunology

authors： Swaminathan B,Matesanz F,Cavanillas ML,Alloza I,Otaegui D,Olascoaga J,Cénit MC,de las Heras V,Barcina MG,Arroyo R,Alcina A,Fernandez O,Antigüedad A,Urcelay E,Vandenbroeck K

更新日期：2010-06-01 00:00:00

abstract：:IL-7 and IL-7Ralpha (IL-7R) form a non-redundant ligand receptor system which plays a crucial role in human T cell immunity. Both IL-7 and IL-7R are multi-exonal genes and exhibit alternative splicing. We measured the relative distribution of IL-7 and IL-7R spliced mRNA from patients with MS and healthy individuals an...

journal_title：Journal of neuroimmunology

authors： Rane L,Vudattu N,Bourcier K,Graniar E,Hillert J,Seyfert V,Maeurer MJ

更新日期：2010-05-01 00:00:00

abstract：:Neurological damage caused by intoxication with Shiga toxin (Stx) from enterohemorrhagic Escherichia coli is the most unrepairable and untreatable outcome of Hemolytic Uremic Syndrome, and occurs in 30% of affected infants. In this work intracerebroventricular administration of Stx2 in rat brains significantly increas...

journal_title：Journal of neuroimmunology

authors： Tironi-Farinati C,Loidl CF,Boccoli J,Parma Y,Fernandez-Miyakawa ME,Goldstein J

更新日期：2010-05-01 00:00:00

abstract：:The role of autoantibody responses in pathogenesis or progression of multiple sclerosis (MS) remains controversial. This is partly because the methods that can distinctly identify pathogenic antibody reactivities targeting native membrane proteins from the reactivities that originate as an epiphenomenon in such diseas...

journal_title：Journal of neuroimmunology

authors： Aslam M,Kalluri SR,Cepok S,Kraus V,Buck D,Srivastava R,Hemmer B

更新日期：2010-04-15 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease with heterogeneous clinical presentations and course. MS is considered to be a T cell mediated disease but in recent years contribution of innate immune cells in mediating MS pathogenesis is being appreciated. In this review, we have discussed the ro...

journal_title：Journal of neuroimmunology

authors： Gandhi R,Laroni A,Weiner HL

更新日期：2010-04-15 00:00:00